1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对食蟹猴黑质神经黑色素超微结构的影响。

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on ultrastructure of nigral neuromelanin in Macaca fascicularis.

作者信息

Levi A C, DeMattei M, Ravazzani R, Corvetti G, Golden G T, Fariello R G

机构信息

Department of Human Anatomy, University of Turin, Medical School, Italy.

出版信息

Neurosci Lett. 1989 Jan 30;96(3):271-6. doi: 10.1016/0304-3940(89)90390-x.

DOI:10.1016/0304-3940(89)90390-x

PMID:2785665

Abstract

In neurons of the substantia nigra (SN) of Macaca fascicularis the administration of parkinsongenic doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused morphological changes of the neuromelanic granules. Under light microscopy, the granules appeared more dispersed and larger. Electron microscopy revealed coalescence of granules in large masses with loss of the electrodense component. Phagocytosis of neuromelanin by glial cells was also observed. In several neurons the neuromelanic changes were evident in the presence of morphologically intact mitochondria. These data suggest an interaction between MPTP and neuromelanin that may have relevance to the nigrotropic toxicity of MPTP and are in agreement with observations on neuromelanin in parkinsonian patients.

摘要

在食蟹猴黑质（SN）神经元中，给予帕金森病致病剂量的1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）会导致神经黑素颗粒出现形态学变化。在光学显微镜下，颗粒显得更加分散且更大。电子显微镜显示颗粒聚集成大块，同时失去电子致密成分。还观察到神经黑素被神经胶质细胞吞噬。在一些神经元中，神经黑素的变化在形态学上完整的线粒体存在时很明显。这些数据表明MPTP与神经黑素之间存在相互作用，这可能与MPTP的黑质毒性有关，并且与帕金森病患者神经黑素的观察结果一致。