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人类对病毒抗原的免疫反应及其与疫苗研发的相关性:世界卫生组织会议纪要

Immune responses to viral antigens in man and their relevance to vaccine development: memorandum from a WHO meeting.

出版信息

Bull World Health Organ. 1983;61(6):935-40.

Abstract

A meeting of an informal working group on immune responses to viral antigens was convened in Amsterdam on 15-18 November 1982 to discuss recent developments in this field and to formulate proposals for international collaborative studies relevant to the needs of the WHO Programme on Vaccine Development. The meeting concluded that the time was ripe for collaborative studies on a wide range of aspects of the immune responses to viral antigens in man. Areas for collaborative effort were defined. These included (a) the role of virus-specific cytotoxic T lymphocytes in virus clearance following infection, (b) correlation of changes in natural killer cells and virus replication, virus virulence, and induction of cytotoxic T lymphocyte, (c) induction of interferons and other mediators of immune responses, and (d) role of individual viral antigens in immune responses. This Memorandum summarizes the discussions and recommendations of the group.

摘要

1982年11月15日至18日,一个关于病毒抗原免疫反应的非正式工作组会议在阿姆斯特丹召开,旨在讨论该领域的最新进展,并就与世卫组织疫苗研发计划需求相关的国际合作研究制定提案。会议得出结论,对人类病毒抗原免疫反应的广泛方面进行合作研究的时机已经成熟。确定了合作努力的领域。其中包括:(a)病毒特异性细胞毒性T淋巴细胞在感染后病毒清除中的作用;(b)自然杀伤细胞变化与病毒复制、病毒毒力以及细胞毒性T淋巴细胞诱导之间的相关性;(c)干扰素和其他免疫反应介质的诱导;(d)单个病毒抗原在免疫反应中的作用。本备忘录总结了该小组的讨论和建议。

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