Clarke K A, Parker A J, Stirk G C
Eur J Pharmacol. 1984 Feb 17;98(2):255-60. doi: 10.1016/0014-2999(84)90597-1.
Previous work has shown that administration of 5HTP in amounts substantially less than those required to elicit 'serotonin syndrome' to rats pretreated witha peripheral decarboxylase inhibitor, produced increases in locomotion, measured by whole body movements. The purpose of the present work was to study the cyclic shifts of weights from side to side which underly the progress of locomotion and to see whether these change after 5HTP. From the reciprocal of the interval for one complete cycle was calculated the weight transferral frequency (WTF). The modal WTF for control and treated rats were in the ranges 1-1.49 and 2-2.49 Hz respectively, while the medians were in the ranges 2-2.49 and 2.5-2.99 Hz respectively. Testing of goodness of fit between the frequency distribution curves in control and treated animals showed significant differences. It is concluded that after 5HTP treatment, basic locomotor patterns are shifted towards higher frequencies.
先前的研究表明，给预先用外周脱羧酶抑制剂处理过的大鼠施用5-羟色氨酸（5HTP），其剂量远低于引发“血清素综合征”所需的剂量，通过全身运动测量，可使运动增加。本研究的目的是研究构成运动过程基础的左右重量的周期性转移，并观察5HTP处理后这些转移是否发生变化。根据一个完整周期的间隔的倒数计算重量转移频率（WTF）。对照大鼠和处理大鼠的模态WTF分别在1 - 1.49赫兹和2 - 2.49赫兹范围内，而中位数分别在2 - 2.49赫兹和2.5 - 2.99赫兹范围内。对照动物和处理动物的频率分布曲线之间的拟合优度检验显示出显著差异。得出的结论是，5HTP处理后，基本运动模式向更高频率转移。
