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针对同基因肿瘤产生溶解性和增殖性淋巴克隆：体外和体内研究

Generation of lytic and proliferative lymphoid clones to syngeneic tumor: in vitro and in vivo studies.

作者信息

Rosenstein M, Rosenberg S A

出版信息

J Natl Cancer Inst. 1984 May;72(5):1161-5.

PMID:6609266
Abstract

T-cell clones that exhibited both lytic and proliferative activity for the syngeneic FBL-3 lymphoma were isolated from in vitro sensitization cultures. These clones were Lyt-2+ and proliferated specifically to the FBL-3 lymphoma but not to other tumors of C57BL/6 origin, allogeneic tumor, or C57BL/6 normal lymphocytes. Adoptive transfer of clones exhibiting both proliferative and cytotoxic activity prolonged survival and occasionally cured the animals of disseminated FBL-3 lymphomas, while T-cell clones exhibiting lytic but no proliferative activity conferred no survival benefit compared to the survival seen among animals receiving no treatment.

摘要

从体外致敏培养物中分离出了对同基因FBL-3淋巴瘤表现出溶解和增殖活性的T细胞克隆。这些克隆为Lyt-2+，能特异性地增殖于FBL-3淋巴瘤，而不增殖于C57BL/6来源的其他肿瘤、同种异体肿瘤或C57BL/6正常淋巴细胞。具有增殖和细胞毒性活性的克隆的过继转移延长了动物的生存期，并且偶尔能治愈播散性FBL-3淋巴瘤，而与未接受治疗的动物的生存期相比，表现出溶解活性但无增殖活性的T细胞克隆未带来生存益处。

相似文献

1
Generation of lytic and proliferative lymphoid clones to syngeneic tumor: in vitro and in vivo studies.针对同基因肿瘤产生溶解性和增殖性淋巴克隆：体外和体内研究
J Natl Cancer Inst. 1984 May;72(5):1161-5.
2
Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen.针对小鼠逆转录病毒诱导的同基因T细胞白血病，会产生不同的增殖性T细胞克隆型：病毒gp70抗原特异性MT4 +克隆和识别肿瘤特异性细胞表面抗原的Lyt-2 +溶细胞克隆。
J Immunol. 1985 Jul;135(1):703-13.
3
Generation of long-term T-lymphoid cell lines with specific cytotoxic reactivity for a syngeneic murine lymphoma.针对同基因小鼠淋巴瘤产生具有特异性细胞毒性反应的长期T淋巴细胞系。
J Natl Cancer Inst. 1982 Jul;69(1):109-16.
4
Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression.用肿瘤特异性细胞毒性T细胞克隆和重组人白细胞介素2对同基因小鼠白血病进行过继性免疫治疗：与克隆性白细胞介素2受体表达的相关性
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Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunologic memory.抗原驱动的T细胞克隆可在体内增殖，根除播散性白血病，并提供特异性免疫记忆。
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J Immunol. 1993 Jun 1;150(11):4900-10.
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Eliciting T cell immunity against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines.通过树突状细胞-肿瘤融合疫苗免疫激发针对低免疫原性肿瘤的T细胞免疫。
J Immunol. 1998 Nov 15;161(10):5516-24.
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Adoptive immunotherapy of syngeneic murine leukemia is enhanced by the combination of recombinant IFN-gamma and a tumor-specific cytotoxic T cell clone.重组干扰素-γ与肿瘤特异性细胞毒性T细胞克隆联合使用可增强同基因小鼠白血病的过继性免疫治疗。
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Therapy of murine leukemia with cyclophosphamide and immune Lyt-2+ cells: cytolytic T cells can mediate eradication of disseminated leukemia.用环磷酰胺和免疫Lyt-2 +细胞治疗小鼠白血病：细胞溶解性T细胞可介导根除播散性白血病。
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引用本文的文献

1
Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon gamma secretion is associated with in vivo therapeutic efficacy of activated tumor-draining lymph node cells.肿瘤特异性粒细胞/巨噬细胞集落刺激因子和干扰素γ的分泌与活化的肿瘤引流淋巴结细胞的体内治疗效果相关。
Cancer Immunol Immunother. 1995 Nov;41(5):317-24. doi: 10.1007/BF01517220.
2
The human mixed lymphocyte-tumor cell interaction test. I. Positive autologous lymphocyte proliferative responses can be stimulated by tumor cells as well as by cells from normal tissues.人类混合淋巴细胞-肿瘤细胞相互作用试验。I. 肿瘤细胞以及正常组织细胞均可刺激自体淋巴细胞产生阳性增殖反应。
Cancer Immunol Immunother. 1984;17(2):83-9. doi: 10.1007/BF00200041.
3
Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.
用环磷酰胺和免疫性Lyt-1⁺、2⁻ T细胞治疗小鼠播散性白血病。肿瘤根除不需要细胞毒性T细胞参与。
J Exp Med. 1985 May 1;161(5):1122-34. doi: 10.1084/jem.161.5.1122.
4
Tumor-derived interleukin-2-dependent lymphocytes in adoptive immunotherapy of lung cancer.肿瘤衍生的白细胞介素-2依赖淋巴细胞在肺癌过继性免疫治疗中的应用
Cancer Immunol Immunother. 1987;24(1):76-85. doi: 10.1007/BF00199837.
5
Mechanisms for recognition of tumor antigens and mediation of anti-tumor effect by noncytolytic Lyt-2+ T cell subset.非细胞溶解性Lyt-2+ T细胞亚群识别肿瘤抗原及介导抗肿瘤效应的机制。
Jpn J Cancer Res. 1988 Jan;79(1):99-108. doi: 10.1111/j.1349-7006.1988.tb00016.x.
6
Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells.抗原驱动的长期培养T细胞在体内增殖，广泛分布，介导特异性肿瘤治疗，并作为功能性记忆T细胞长期持续存在。
J Exp Med. 1986 May 1;163(5):1100-12. doi: 10.1084/jem.163.5.1100.
7
Helper strategy in tumor immunology: expansion of helper lymphocytes and utilization of helper lymphokines for experimental and clinical immunotherapy.肿瘤免疫学中的辅助策略：辅助淋巴细胞的扩增及辅助淋巴因子在实验性和临床免疫治疗中的应用
Cancer Metastasis Rev. 1988 Dec;7(4):289-309. doi: 10.1007/BF00051371.
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Mediation of in vivo tumor-neutralizing activity by Lyt-2+ as well as L3T4+ T cell subsets.Lyt-2+以及L3T4+ T细胞亚群对体内肿瘤中和活性的介导作用。
Jpn J Cancer Res. 1988 Jan;79(1):91-8. doi: 10.1111/j.1349-7006.1988.tb00015.x.
9
The effect of cimetidine on PBL from healthy donors and melanoma patients: augmentation of T cell responses to TCGF mitogens and alloantigens and of TCGF production.西咪替丁对健康供体和黑色素瘤患者外周血淋巴细胞的作用：增强T细胞对T细胞生长因子有丝分裂原和同种抗原的反应以及T细胞生长因子的产生。
Cancer Immunol Immunother. 1986;21(2):141-7. doi: 10.1007/BF00199862.
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The roles of CD8+ and CD4+ cells in tumor rejection.CD8⁺和CD4⁺细胞在肿瘤排斥反应中的作用。
Jpn J Cancer Res. 1989 Jul;80(7):649-54. doi: 10.1111/j.1349-7006.1989.tb01692.x.