被钙内流阻滞剂D600麻痹的骨骼肌纤维中的电荷移动。
Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.
作者信息
Hui C S, Milton R L, Eisenberg R S
出版信息
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2582-5. doi: 10.1073/pnas.81.8.2582.
Abstract
We report measurements of nonlinear charge movement in frog skeletal muscle fibers paralyzed by the calcium-entry blocker [Schwartz, A. & Taira, N., eds. (1983) Circ. Res. 52, Part II, Number 2, 1-181.] D600 (methoxyverapamil, recently renamed gallopamil). Nonlinear charge movement was not seen in such fibers, suggesting that the drug severs the link between membrane depolarization and the main components of charge movement. This is the only pharmacological agent that blocks the main components of charge movement.
摘要
我们报告了对被钙内流阻滞剂[施瓦茨，A.和Taira，N.，编辑（1983年）《循环研究》52，第二部分，第2期，1 - 181页]D600（甲氧基维拉帕米，最近重新命名为加洛帕米）麻痹的青蛙骨骼肌纤维中非线性电荷移动的测量。在这些纤维中未观察到非线性电荷移动，这表明该药物切断了膜去极化与电荷移动主要成分之间的联系。这是唯一一种能阻断电荷移动主要成分的药剂。
相似文献
1
Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.被钙内流阻滞剂D600麻痹的骨骼肌纤维中的电荷移动。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2582-5. doi: 10.1073/pnas.81.8.2582.
2
Suppression of charge movement in frog skeletal muscle by D600.D600对青蛙骨骼肌电荷移动的抑制作用。
J Muscle Res Cell Motil. 1987 Jun;8(3):195-208. doi: 10.1007/BF01574588.
3
Effects of gallopamil on calcium release and intramembrane charge movements in frog skeletal muscle fibres.加洛帕米对蛙骨骼肌纤维钙释放及膜内电荷移动的影响。
J Physiol. 1990 Feb;421:343-62. doi: 10.1113/jphysiol.1990.sp017948.
4
D600 binding sites on voltage-sensors for excitation-contraction coupling in frog skeletal muscle are intracellular.
J Muscle Res Cell Motil. 1990 Dec;11(6):471-88. doi: 10.1007/BF01745215.
5
The action of D600 on frog skeletal muscle: facilitation of excitation-contraction coupling.
Pflugers Arch. 1977 Jul 19;369(3):259-67. doi: 10.1007/BF00582193.
6
Effects of D-600 on intramembrane charge movement of polarized and depolarized frog muscle fibers.D-600对极化和去极化青蛙肌肉纤维膜内电荷移动的影响。
J Gen Physiol. 1989 Jul;94(1):43-64. doi: 10.1085/jgp.94.1.43.
7
Effects of lanthanum on contractile inactivation and D600-induced paralysis in twitch muscle fibres of the frog.镧对青蛙单收缩肌纤维收缩失活及D600诱导麻痹的影响。
Pflugers Arch. 1989 Jul;414(3):373-5. doi: 10.1007/BF00584642.
8
Paralysis of frog skeletal muscle fibres by the calcium antagonist D-600.钙拮抗剂D - 600对青蛙骨骼肌纤维的麻痹作用
J Physiol. 1983 Aug;341:495-505. doi: 10.1113/jphysiol.1983.sp014819.
9
D600 prolongs inactivation of the contractile system in frog twitch fibres.D600可延长青蛙单收缩肌纤维收缩系统的失活时间。
Pflugers Arch. 1987 Sep;410(1-2):75-82. doi: 10.1007/BF00581899.
10
Calcium influx in contracting and paralyzed frog twitch muscle fibers.收缩和麻痹的青蛙抽动肌纤维中的钙内流。
J Gen Physiol. 1985 Mar;85(3):383-408. doi: 10.1085/jgp.85.3.383.
引用本文的文献
1
Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation.骨骼肌激活中双向性二氢吡啶和兰尼碱受体的相互作用。
J Muscle Res Cell Motil. 2011 Nov;32(3):171-202. doi: 10.1007/s10974-011-9262-9. Epub 2011 Oct 13.
2
Properties and roles of an intramembranous charge mobilized at high voltages in frog skeletal muscle.青蛙骨骼肌中在高电压下动员的膜内电荷的特性和作用。
J Physiol. 1995 Jul 15;486 ( Pt 2)(Pt 2):385-400. doi: 10.1113/jphysiol.1995.sp020820.
3
Calcium influx in contracting and paralyzed frog twitch muscle fibers.收缩和麻痹的青蛙抽动肌纤维中的钙内流。
J Gen Physiol. 1985 Mar;85(3):383-408. doi: 10.1085/jgp.85.3.383.
4
Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine.兔骨骼肌中电荷移动的组成部分：丁卡因和硝苯地平的作用。
J Physiol. 1986 Jul;376:85-100. doi: 10.1113/jphysiol.1986.sp016143.
5
Potassium contractures and asymmetric charge movement in extensor digitorum longus and soleus muscles from thyrotoxic rats.甲状腺毒症大鼠趾长伸肌和比目鱼肌中的钾挛缩和不对称电荷移动
J Muscle Res Cell Motil. 1987 Aug;8(4):289-96. doi: 10.1007/BF01568885.
6
Contractile inactivation in frog skeletal muscle fibers. The effects of low calcium, tetracaine, dantrolene, D-600, and nifedipine.青蛙骨骼肌纤维中的收缩失活。低钙、丁卡因、丹曲林、D - 600和硝苯地平的作用。
J Gen Physiol. 1987 Mar;89(3):421-42. doi: 10.1085/jgp.89.3.421.
7
D600 prolongs inactivation of the contractile system in frog twitch fibres.D600可延长青蛙单收缩肌纤维收缩系统的失活时间。
Pflugers Arch. 1987 Sep;410(1-2):75-82. doi: 10.1007/BF00581899.
8
Effects of the calcium antagonist gallopamil (D600) upon excitation-contraction coupling in toe muscle fibres of the frog.钙拮抗剂加洛帕米（D600）对青蛙趾肌纤维兴奋-收缩偶联的影响。
J Physiol. 1987 Apr;385:693-707. doi: 10.1113/jphysiol.1987.sp016515.
9
The effect of D600 on potassium contractures of slow muscle fibres of Rana temporaria.D600对林蛙慢肌纤维钾挛缩的影响。
Pflugers Arch. 1988 Sep;412(4):390-6. doi: 10.1007/BF01907557.
10
Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling.青蛙骨骼肌膜的电压传感器在兴奋-收缩偶联过程中发挥作用需要钙。
J Physiol. 1988 Apr;398:475-505. doi: 10.1113/jphysiol.1988.sp017053.
本文引用的文献
1
Potassium contractures in single muscle fibres.单根肌纤维中的钾挛缩
J Physiol. 1960 Sep;153(2):386-403. doi: 10.1113/jphysiol.1960.sp006541.
2
A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
3
Electrical models of excitation-contraction coupling and charge movement in skeletal muscle.骨骼肌中兴奋-收缩偶联与电荷移动的电学模型。
J Gen Physiol. 1980 Jul;76(1):1-31. doi: 10.1085/jgp.76.1.1.
4
Permeability of canine cardiac sarcoplasmic reticulum vesicles to K+, Na+, H+, and Cl-.犬心肌肌浆网囊泡对钾离子、钠离子、氢离子和氯离子的通透性。
J Biol Chem. 1982 Jul 10;257(13):7704-11.
5
Calcium release in skinned cardiac cells: variations with species, tissues, and development.去表皮心肌细胞中的钙释放：因物种、组织和发育阶段而异
Fed Proc. 1982 May;41(7):2238-44.
6
Pharmacological separation of charge movement components in frog skeletal muscle.青蛙骨骼肌中电荷移动成分的药理学分离
J Physiol. 1982 Mar;324:375-87. doi: 10.1113/jphysiol.1982.sp014118.
7
Voltage-dependent charge movement in frog slow muscle fibres.青蛙慢肌纤维中电压依赖性电荷移动
J Physiol. 1980 Apr;301:175-90. doi: 10.1113/jphysiol.1980.sp013197.
8
Membrane electrical properties of frog slow muscle fibres.青蛙慢肌纤维的膜电特性
J Physiol. 1980 Apr;301:157-73. doi: 10.1113/jphysiol.1980.sp013196.
9
Experimental analysis of alternative models of charge movement in frog skeletal muscle.青蛙骨骼肌中电荷移动替代模型的实验分析。
J Physiol. 1983 Mar;336:527-43. doi: 10.1113/jphysiol.1983.sp014596.
10
Paralysis of frog skeletal muscle fibres by the calcium antagonist D-600.钙拮抗剂D - 600对青蛙骨骼肌纤维的麻痹作用
J Physiol. 1983 Aug;341:495-505. doi: 10.1113/jphysiol.1983.sp014819.
Zotero 插件