Kessler R M, Ellis J R, Eden M
J Comput Assist Tomogr. 1984 Jun;8(3):514-22. doi: 10.1097/00004728-198406000-00028.
The proper analysis of positron emission tomographic scan data requires a careful knowledge of the limitations of the tomographic system used so that scan data can be collected and sampled in a manner consistent with those limitations. The present investigation was undertaken to clarify some of the limitations imposed by resolution. The usual imaging situation, e.g., 218FDG , C15O2, or 15O2 , involves imaging structures of limited size in all three dimensions which may appear either warm or cool in relation to some background level of activity. In emission tomography the importance of adequate data sampling within a given plane has been frequently emphasized. Little attention, however, has been given to proper z axis sampling for clinical scanning. The actual selection of regions of interest from scans can have a significant impact on the subsequent statistical analysis. Previous work on this subject has experimentally examined the relationship of object size to quantitative estimation in the hot spot-cold background situation for the one- and two-dimensional cases. Approximate three-dimensional recovery coefficients for the hot spot-cold background situation have been calculated. An examination of the factors discussed above, three-dimensional objects with varying contrast, z axis sampling, and selection of regions of interest, has not yet been addressed in the literature. The purpose of the present investigation is to examine these factors.
对正电子发射断层扫描数据进行恰当分析，需要深入了解所用断层扫描系统的局限性，以便能按照与这些局限性相符的方式采集和采样扫描数据。本研究旨在阐明分辨率所带来的一些局限性。通常的成像情况，例如使用(^{18}FDG)、(C^{15}O_2)或(^{15}O_2)成像时，涉及对三维空间中尺寸有限的结构进行成像，这些结构相对于某种背景活动水平可能呈现为热区或冷区。在发射断层扫描中，人们经常强调在给定平面内进行充分数据采样的重要性。然而，对于临床扫描时在(z)轴上进行恰当采样却很少有人关注。从扫描图像中实际选择感兴趣区域会对后续的统计分析产生重大影响。此前关于这个主题的工作已经通过实验研究了在热点 - 冷背景情况下，一维和二维情形中物体大小与定量估计之间的关系。已经计算出了热点 - 冷背景情况下近似的三维恢复系数。文献中尚未涉及对上述因素的研究，即具有不同对比度的三维物体、(z)轴采样以及感兴趣区域的选择。本研究的目的就是考察这些因素。
