Meltzer C C, Bryan R N, Holcomb H H, Kimball A W, Mayberg H S, Sadzot B, Leal J P, Wagner H N, Frost J J
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
J Comput Assist Tomogr. 1990 May-Jun;14(3):418-26. doi: 10.1097/00004728-199005000-00019.
Accurate localization of an imaging plane of interest is often needed prior to a positron emission tomographic (PET) study. We have developed a simple method for accurate and reproducible selection of an imaging plane for PET using magnetic resonance (MR) imaging. This method is useful when optimal sampling of specific brain structures, such as small subcortical nuclei, or when a specific imaging angle is required for the PET study. An external localizing device, consisting of a series of tubes visible on MR, is affixed to an individually fitted thermoplastic mask. This mask system is worn by the patient during both the MR and PET studies. A plane of interest is planned from the sagittal MR image and defined by its relation to the localizing device and to the MR scanner's "landmark" or reference position. This plane is transferred to the mask by means of a calibrated alignment laser. The coplanar acquisition of MR and PET images allows individualized analysis of brain structure-function relationships. Phantom studies demonstrated the accuracy and reproducibility of imaging plane selection by this method to be within 1 mm and 1 degree. Application of the localization protocol in a human subject is also presented.
在进行正电子发射断层扫描（PET）研究之前，通常需要对感兴趣的成像平面进行精确的定位。我们已经开发出一种简单的方法，利用磁共振（MR）成像为PET准确且可重复地选择成像平面。当需要对特定脑结构（如小的皮质下核团）进行最佳采样时，或者当PET研究需要特定的成像角度时，这种方法很有用。一个外部定位装置，由一系列在MR上可见的管子组成，固定在一个单独定制的热塑性面罩上。在MR和PET研究期间，患者都佩戴这个面罩系统。从矢状面MR图像规划出感兴趣的平面，并根据其与定位装置以及MR扫描仪的“地标”或参考位置的关系来定义。这个平面通过校准的对准激光转移到面罩上。MR和PET图像的共面采集允许对脑结构 - 功能关系进行个体化分析。模型研究表明，通过这种方法选择成像平面的准确性和可重复性在1毫米和1度以内。还介绍了该定位方案在人体受试者中的应用。
