Norris S L, Slutsky R A, Gerber K H, Geiss K R, Ashburn W L, Higgins C B
Am J Cardiol. 1984 Jun 1;53(11):1547-52. doi: 10.1016/0002-9149(84)90577-0.
Phase standard deviation (SD) and skew characteristics of the first Fourier harmonic of equilibrium radionuclide volume curves were examined and compared during rest and during supine bicycle exercise with ejection fraction (EF) changes and the development of ischemia in 17 control subjects and in 2 groups of patients (n = 57) with coronary artery disease (CAD). Group I comprised 37 patients with CAD; IA was a subgroup of 20 patients with previous myocardial infarction (MI) and IB a subgroup of 17 patients with CAD without MI (all with coronary stenosis greater than 75% diameter narrowing). Group II comprised 20 patients with CAD who had undergone coronary bypass surgery. In the Group I subjects, phase SD was the most sensitive indicator of CAD at rest (Group I, 56%; Group IA, 70%, and Group IB, 29%), and the EF was the most sensitive indicator at submaximal (Group I, 78%; Group IA, 86%, and Group IB, 64%) and maximal exercise (Group I, 70%; Group IA, 93%, and Group IB, 53%). When phase SD and skewness were combined with EF changes, little increase in sensitivity occurred in Group I (rest 61%, submaximal exercise 88% and maximal exercise 76%). The results from Group II subgroups were qualitatively similar to those observed with Group I subgroups. These data reveal a marginally improved sensitivity for detection of CAD during supine bicycle radionuclide ventriculography when phase measurements were added to changes in global EF values.
在17名对照受试者以及两组冠心病（CAD）患者（n = 57）中，研究并比较了静息状态和仰卧位自行车运动期间平衡放射性核素容积曲线的一次傅里叶谐波的相位标准差（SD）和偏度特征，同时观察了射血分数（EF）变化和缺血的发展情况。第一组包括37例CAD患者；IA亚组为20例有既往心肌梗死（MI）的患者，IB亚组为17例无MI的CAD患者（均有冠状动脉狭窄，直径狭窄大于75%）。第二组包括20例接受冠状动脉搭桥手术的CAD患者。在第一组受试者中，相位SD是静息状态下CAD最敏感的指标（第一组为56%；IA组为70%，IB组为29%），而EF是次极量运动（第一组为78%；IA组为86%，IB组为64%）和极量运动（第一组为70%；IA组为93%，IB组为53%）时最敏感的指标。当将相位SD和偏度与EF变化相结合时，第一组的敏感性几乎没有增加（静息时为61%，次极量运动时为88%，极量运动时为76%）。第二组亚组的结果在质量上与第一组亚组观察到的结果相似。这些数据表明，在仰卧位自行车放射性核素心室造影中，当在整体EF值变化基础上增加相位测量时，检测CAD的敏感性略有提高。
