Lukaszewska I, Markowska A
Acta Neurobiol Exp (Wars). 1983;43(2):79-88.
We attempted to test whether the effect of amygdaloid lesion on the response-to-change would be similar to that observed previously after hippocampal damage. Twelve rats with lesions in the cortico-basomedial region of the amygdala (CBM) and 20 sham operated controls were used. The experiment was conducted in a T-maze under two different conditions of stimulus presentation in trial 1. In the passive test the rat was allowed to inspect the white-black maze arms, but was prevented from entering them by transparent partitions. In the active test the rat was permitted to explore the entire T-maze. In both tests, the brightness of one arm was changed in trial 2, so that the two arms were alike. Control rats showed a statistically significant pre-ponderance of choices of the changed arm in both tests. CBM rats responded on a chance level in the passive test, while in the active one they performed like controls. These results, replicating closely the previous findings on rats with hippocampal damage, indicate the involvement of both the amygdala and hippocampus in the passive version of the response-to-change test. The postoperative disturbance might be interpreted as an attentional deficit or a selective impairment of information processing in the passive version of the test.
我们试图测试杏仁核损伤对变化反应的影响是否与先前观察到的海马损伤后的影响相似。使用了12只杏仁核皮质-基底内侧区域（CBM）有损伤的大鼠和20只假手术对照组大鼠。实验在T形迷宫中进行，在试验1中有两种不同的刺激呈现条件。在被动测试中，大鼠被允许检查黑白相间的迷宫臂，但被透明隔板阻止进入。在主动测试中，大鼠被允许探索整个T形迷宫。在两种测试中，试验2时改变了其中一个臂的亮度，使两个臂变得一样。对照组大鼠在两种测试中对改变臂的选择都有统计学上显著的优势。CBM大鼠在被动测试中随机做出反应，而在主动测试中它们的表现与对照组相似。这些结果与先前对海马损伤大鼠的研究结果非常相似，表明杏仁核和海马体都参与了变化反应测试的被动版本。术后的干扰可能被解释为注意力缺陷或测试被动版本中信息处理的选择性损伤。
