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吡拉西坦降低镰状红细胞对培养的血管内皮的黏附性。

Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam.

作者信息

Nalbandian R M, Henry R L, Burek C L, Diglio C A, Goldman A I, Taylor G W, Hoffman W H

出版信息

Am J Hematol. 1983 Sep;15(2):147-51. doi: 10.1002/ajh.2830150206.

DOI:10.1002/ajh.2830150206
PMID:6613985
Abstract

Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.

摘要

将来自正常供体和镰状细胞供体的红细胞置于培养的大鼠血管内皮细胞层上进行孵育。尽管两类供体的红细胞与内皮细胞的黏附情况相当,但无论供体如何,添加1.5 mM的吡拉西坦均可显著降低这种黏附。

相似文献

1
Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam.吡拉西坦降低镰状红细胞对培养的血管内皮的黏附性。
Am J Hematol. 1983 Sep;15(2):147-51. doi: 10.1002/ajh.2830150206.
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Effect of piracetam on sickle erythrocytes and sickle hemoglobin.吡拉西坦对镰状红细胞和镰状血红蛋白的作用。
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Piracetam and sickle-cell disease.吡拉西坦与镰状细胞病
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Erythrocyte - endothelial cell adherence in sickle cell disease, diabetes mellitus, and falciparum malaria: adverse effects reversed with piracetam.镰状细胞病、糖尿病和恶性疟疾中的红细胞 - 内皮细胞黏附:吡拉西坦可逆转不良影响。
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Blockade of adhesion of sickle cells to endothelium by monoclonal antibodies.单克隆抗体对镰状细胞与内皮细胞黏附的阻断作用。
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Sickle erythrocyte adherence to large vessel and microvascular endothelium under physiologic flow is qualitatively different.在生理血流条件下,镰状红细胞与大血管和微血管内皮的黏附在性质上有所不同。
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Sickle erythrocyte adherence to vascular endothelium. Morphologic correlates and the requirement for divalent cations and collagen-binding plasma proteins.镰状红细胞与血管内皮的黏附。形态学关联以及对二价阳离子和胶原结合血浆蛋白的需求。
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引用本文的文献

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Pharmacokinetic Study of Piracetam in Focal Cerebral Ischemic Rats.吡拉西坦在局灶性脑缺血大鼠中的药代动力学研究
Eur J Drug Metab Pharmacokinet. 2018 Apr;43(2):205-213. doi: 10.1007/s13318-017-0435-9.
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Piracetam Attenuates LPS-Induced Neuroinflammation and Cognitive Impairment in Rats.吡拉西坦可减轻 LPS 诱导的大鼠神经炎症和认知障碍。
Cell Mol Neurobiol. 2017 Nov;37(8):1373-1386. doi: 10.1007/s10571-017-0468-2. Epub 2017 Feb 7.
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Piracetam: a review of pharmacological properties and clinical uses.吡拉西坦:药理特性与临床应用综述
CNS Drug Rev. 2005 Summer;11(2):169-82. doi: 10.1111/j.1527-3458.2005.tb00268.x.
4
Use of piracetam improves sickle cell deformability in vitro and in vivo.使用吡拉西坦可在体外和体内改善镰状细胞的可变形性。
J Clin Pathol. 1987 Jan;40(1):99-102. doi: 10.1136/jcp.40.1.99.
5
Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders.
Drugs Aging. 1991 Jan;1(1):17-35. doi: 10.2165/00002512-199101010-00004.