Collins J M, Dedrick R L
Am J Physiol. 1983 Sep;245(3):R303-10. doi: 10.1152/ajpregu.1983.245.3.R303.
Measurements of drug concentration in cerebrospinal fluid (CSF) provide the most accessible index of drug delivery to the brain. Our perception of the blood-brain barrier has been largely shaped by these measurements. A crucial question for the interpretation of these data is the nature of the relationships between drug concentration in CSF and the drug concentration profile in brain tissue. A distributed model for the delivery of drugs via plasma to brain tissue and CSF is presented, and the relationships between capillary exchange, tissue diffusion, and CSF turnover rate are explored. The effects of blood-brain barrier disruption on tissue and CSF concentrations are also simulated.
脑脊液（CSF）中药物浓度的测量提供了药物向脑内递送的最易获取指标。我们对血脑屏障的认识在很大程度上是由这些测量结果塑造的。解释这些数据的一个关键问题是脑脊液中药物浓度与脑组织中药物浓度分布之间关系的本质。本文提出了一种通过血浆将药物递送至脑组织和脑脊液的分布式模型，并探讨了毛细血管交换、组织扩散和脑脊液周转率之间的关系。还模拟了血脑屏障破坏对组织和脑脊液浓度的影响。
