Cox J L, Harrison S D
Biochem Biophys Res Commun. 1983 Aug 30;115(1):106-11. doi: 10.1016/0006-291x(83)90975-0.
A fundamental biochemical process that is directly and universally related to the toxicity of metals and metal compounds has yet to be identified. Results of studies reported here indicate that the toxicity of a series of divalent metal cations correlates well with the metals' ability to inhibit the Ca2+ receptor protein calmodulin (r = 0.986). Because calmodulin regulates a variety of cellular enzymes and processes including intracellular Ca2+ concentrations, calmodulin inhibition may have value for predicting metal toxicity and for revealing information about the mechanism by which metals induce toxic effects.
一种与金属及金属化合物毒性直接且普遍相关的基本生化过程尚未被确定。此处报道的研究结果表明，一系列二价金属阳离子的毒性与这些金属抑制Ca2+受体蛋白钙调蛋白的能力密切相关（r = 0.986）。由于钙调蛋白调节多种细胞酶及过程，包括细胞内Ca2+浓度，抑制钙调蛋白可能对于预测金属毒性以及揭示金属诱导毒性效应的机制具有价值。
