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1
The effect of long-term colchicine therapy in patients with recurrent polyserositis on the capacity of blood platelets to synthesize thromboxane A2.长期秋水仙碱治疗对复发性多浆膜炎患者血小板合成血栓素A2能力的影响。
Br J Clin Pharmacol. 1983 Aug;16(2):191-4. doi: 10.1111/j.1365-2125.1983.tb04985.x.
2
The effect of oral administration of dipyrone on the capacity of blood platelets to synthesize thromboxane A2 in man.口服安乃近对人体血小板合成血栓素A2能力的影响。
Eur J Clin Pharmacol. 1984;26(2):171-6. doi: 10.1007/BF00630282.
3
Inhibition of thromboxane A2 biosynthesis in human platelets by burimamide.布立马胺对人血小板中血栓素A2生物合成的抑制作用。
Br J Pharmacol. 1980;71(1):157-64. doi: 10.1111/j.1476-5381.1980.tb10920.x.
4
Effects of heparin on platelet aggregation and release and thromboxane A2 production.肝素对血小板聚集、释放及血栓素A2生成的影响。
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5
Bleeding disorder associated with albumin-dependent partial deficiency in platelet thromboxane production. Effect of albumin on arachidonate metabolism in platelets.与血小板血栓素生成中白蛋白依赖性部分缺乏相关的出血性疾病。白蛋白对血小板中花生四烯酸代谢的影响。
Am J Clin Pathol. 1985 Jun;83(6):687-96. doi: 10.1093/ajcp/83.6.687.
6
Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine.新生儿与成人血小板在对花生四烯酸和肾上腺素反应时血栓素生成的差异。
Pediatr Res. 1984 Sep;18(9):823-6. doi: 10.1203/00006450-198409000-00003.
7
Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment.冠状动脉狭窄患者中无血小板滞留的经冠状动脉血小板血栓素A2生成——磺吡酮治疗的影响
Thromb Haemost. 1983 Dec 30;50(4):857-9.
8
Why do some beta adrenergic agonists inhibit generation of thromboxane A2 in incubates of platelets with arachidonic acid?为什么某些β-肾上腺素能激动剂在血小板与花生四烯酸的孵育物中会抑制血栓素A2的生成？
Biochem Pharmacol. 1978;27(11):1603-6. doi: 10.1016/0006-2952(78)90492-6.
9
Plasma colchicine concentration in patients with recurrent polyserositis (familial Mediterranean fever) on long-term prophylaxis.
Arthritis Rheum. 1982 Feb;25(2):227-31. doi: 10.1002/art.1780250219.
10
Effect of nicotine on fetal prostacyclin and thromboxane in humans.尼古丁对人体胎儿前列环素和血栓素的影响。
Obstet Gynecol. 1985 Jul;66(1):102-5.

本文引用的文献

1
Familial Mediterranean fever.家族性地中海热
AMA Arch Intern Med. 1958 Jul;102(1):50-71. doi: 10.1001/archinte.1958.00260190052007.
2
Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function.血清血栓素B2的放射免疫测定：一种评估药物对血小板功能影响的简单方法。
Adv Prostaglandin Thromboxane Res. 1980;6:187-91.
3
Plasma colchicine concentration in patients with recurrent polyserositis (familial Mediterranean fever) on long-term prophylaxis.
Arthritis Rheum. 1982 Feb;25(2):227-31. doi: 10.1002/art.1780250219.
4
Vincristine inhibits the synthesis of malondialdehyde by human platelets in vitro.
Cancer. 1982 Feb 15;49(4):665-8. doi: 10.1002/1097-0142(19820215)49:4<665::aid-cncr2820490413>3.0.co;2-y.
5
Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells.硝酸甘油可刺激培养的人内皮细胞合成前列环素。
J Clin Invest. 1981 Mar;67(3):762-9. doi: 10.1172/JCI110093.
6
Platelets and microtubules. Effect of colchicine and D2O on platelet aggregation and release induced by calcium ionophore A23187.血小板与微管。秋水仙碱和重水对钙离子载体A23187诱导的血小板聚集和释放的影响。
J Clin Invest. 1980 Aug;66(2):284-91. doi: 10.1172/JCI109855.
7
Effects of colchicine and vinca alkaloids on human platelets. 3. Influence on primary internal contraction and secondary aggregation.秋水仙碱和长春花生物碱对人血小板的作用。3. 对原发性内收缩和继发性聚集的影响。
Am J Pathol. 1969 Mar;54(3):467-78.
8
Effects of colchicine and Vinca alkaloids on human platelets. I. Influence on platelet microtubules and contractile function.秋水仙碱和长春花生物碱对人血小板的作用。I. 对血小板微管和收缩功能的影响。
Am J Pathol. 1968 Aug;53(2):281-91.
9
Platelet factor 3 activity made available from human platelets by ADP. Inhibition by colchicine.由二磷酸腺苷（ADP）从人血小板中释放出的血小板因子3活性。秋水仙碱的抑制作用。
Thromb Diath Haemorrh. 1973 Sep 15;30(1):155-9.
10
Radioimmunological assay of prostaglandin synthetase activity.前列腺素合成酶活性的放射免疫测定
Prostaglandins. 1973 Sep;4(3):313-24. doi: 10.1016/0090-6980(73)90019-1.

长期秋水仙碱治疗对复发性多浆膜炎患者血小板合成血栓素A2能力的影响。

The effect of long-term colchicine therapy in patients with recurrent polyserositis on the capacity of blood platelets to synthesize thromboxane A2.

作者信息

Levy M, Eldor A, Zylber-Katz E, Eliakim M

出版信息

Br J Clin Pharmacol. 1983 Aug;16(2):191-4. doi: 10.1111/j.1365-2125.1983.tb04985.x.

DOI:10.1111/j.1365-2125.1983.tb04985.x
PMID:6615693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1427989/
Abstract

Thromboxane B2 (TXB) production during platelet activation was measured in 13 patients with recurrent polyserositis on long-term colchicine therapy and 10 healthy controls. Plasma colchicine concentration in patients ranged between 0.8-7.8 ng/ml (2.0-19.5 X 10(-9) M). Thromboxane production induced during aggregation by arachidonic acid or collagen and serum TXB2 levels (clotted blood, 37 degrees C, 1 h) did not differ among patients and controls. Previous studies reporting platelet function defects including anomalous TXB2 production, were performed in vitro using colchicine concentrations markedly exceeding the therapeutic range.

摘要

在13例接受长期秋水仙碱治疗的复发性多浆膜炎患者和10名健康对照者中，检测了血小板激活过程中血栓素B2（TXB）的生成情况。患者血浆秋水仙碱浓度在0.8 - 7.8 ng/ml（2.0 - 19.5×10⁻⁹ M）之间。花生四烯酸或胶原诱导聚集过程中产生的血栓素以及血清TXB2水平（凝血，37℃，1小时）在患者和对照者之间没有差异。先前报道血小板功能缺陷（包括异常TXB2生成）的研究是在体外使用明显超过治疗范围的秋水仙碱浓度进行的。