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[致癌腺病毒SA7(C8)诱导的核染色质结构变化的细胞光度学研究]

[Cytophotometric study of changes in the structure of nuclear chromatin induced by the oncogenic adenovirus SA7 (C8)].

作者信息

Kotel'nikova I N, Ageenko A I, Khristenko A V

出版信息

Biull Eksp Biol Med. 1983 Sep;96(9):80-2.

PMID:6616062
Abstract

Infection of primary murine embryonic cell cultures by adenovirus SA7 (C8) results in an increase in chromatin condensation Average optical density of Feulgen stained nuclei 24 h following virus absorption increased for G0/1, S, and G2 cells by 16.1, 11.3 and 13.1%, respectively. This phenomenon is associated with the stimulation of proliferation, with an increase of the S cell amount by 50% of the control values and a decrease of average cell nuclei areas in all phases of cell cycle.

摘要

腺病毒SA7(C8)感染原代小鼠胚胎细胞培养物会导致染色质凝聚增加。病毒吸附后24小时,G0/1期、S期和G2期细胞经福尔根染色的细胞核平均光密度分别增加了16.1%、11.3%和13.1%。这种现象与增殖刺激有关,S期细胞数量比对照值增加了50%,且细胞周期各阶段的平均细胞核面积减小。

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