Aylward M, Davies D E, Maddock J, Robinson P R, Jones M
Cephalalgia. 1983 Aug;3 Suppl 1:146-50. doi: 10.1177/03331024830030S123.
With the combined pharmacokinetic-pharmacodynamic approach, the bioavailability and venoconstrictor effects of two DHE formulations (programmed release capsules and oral solution) have been compared after acute oral dose administrations in the healthy volunteer subjects. The bioavailability of DHE from programmed release capsules has been significantly greater than that shown by the oral solution. DHE capsules formulation has seemed to provide appropriate plasma concentrations for at least 10 h after administration. That may well account for its efficacy in the treatment of morning migraine.
采用药代动力学-药效学联合方法，在健康志愿者受试者中急性口服给药后，比较了两种去氢表雄酮制剂（缓释胶囊和口服溶液）的生物利用度和血管收缩作用。缓释胶囊中去氢表雄酮的生物利用度显著高于口服溶液。去氢表雄酮胶囊制剂给药后似乎能在至少10小时内维持适当的血浆浓度。这很可能解释了其在治疗晨起偏头痛方面的疗效。
