Powell P C, Payne L N, Frazier J A, Rennie M
IARC Sci Publ (1971). 1975(11 Pt 2):89-99.
The establishment and continuous culture of two lymphoblastoid cell lines derived from Marek's disease lymphomas is described. Although the cells carried T-lymphocyte surface antigens, they had many features in common with cultured Burkitt's lymphoma lymphoblasts, which carry B-cell determinants. A small proportion acted as infectious units in tissue culture, and a similarly small proportion contained intranuclear immature herpesvirus particles. The cells did not respond to phytohaemagglutinin. One cell line possessed some graft-versus-host capacity, as measured by the induction of splenomegaly. It is concluded that the development of acute Marek's disease involves the malignant transformation of thymus-dependent lymphocytes by Marek's disease virus.
本文描述了源自马立克氏病淋巴瘤的两个淋巴母细胞系的建立及连续培养情况。尽管这些细胞携带T淋巴细胞表面抗原，但它们具有许多与携带B细胞决定簇的培养伯基特淋巴瘤淋巴母细胞相同的特征。一小部分细胞在组织培养中充当感染单位，同样一小部分细胞含有核内未成熟疱疹病毒颗粒。这些细胞对植物血凝素无反应。通过脾肿大的诱导来衡量，一个细胞系具有一定的移植物抗宿主能力。得出的结论是，急性马立克氏病的发展涉及马立克氏病病毒对胸腺依赖性淋巴细胞的恶性转化。
