Maucher O M, Fuchs A
Hautarzt. 1983 Aug;34(8):383-6.
About one third of patients with anaphylactic reactions to pyrazolones showed contact urticaria induced by to at least one pyrazolone after 30-60 min in patch test. This reaction was never observed in patients with various exanthemas or allergic contact dermatitis to these medicaments. Contact urticaria in patch test was mostly caused by propyphenazone, aminophenazone, and metamizole. The suspicious pyrazolone provoked positive results in only about 70%. No correlation could be found between contact urticaria in patch test and severity of allergic history, short interval before skin test and atopic constitution.
对吡唑酮类药物有过敏反应的患者中，约三分之一在斑贴试验30 - 60分钟后，对至少一种吡唑酮类药物产生接触性荨麻疹。在对这些药物有各种皮疹或过敏性接触性皮炎的患者中从未观察到这种反应。斑贴试验中的接触性荨麻疹主要由保泰松、氨基比林和安乃近引起。可疑的吡唑酮类药物仅在约70%的情况下引发阳性结果。斑贴试验中的接触性荨麻疹与过敏史的严重程度、皮肤试验前的短时间间隔和特应性体质之间未发现相关性。
