Johnson D M, Taylor W F, Thompson G F, Pritchard R A
J Pharm Sci. 1983 Aug;72(8):946-8. doi: 10.1002/jps.2600720828.
The degradation of the prostaglandin fenprostalene (III) was studied in aqueous solution. The reaction was both specific acid and base catalyzed. The only reaction found to occur was hydrolysis of the methyl ester at C-1. Activation energies for the acid- and base-catalyzed reactions were determined and are nearly identical to that for the hydrolysis of ethyl acetate, a model ester. A competing acid-catalyzed reaction of the C-1 free acid of III was found to be approximately 10 times slower than the hydrolysis of III.
在水溶液中研究了前列腺素非那前列烯（III）的降解情况。该反应同时受到特定的酸和碱催化。发现唯一发生的反应是C-1位甲酯的水解。测定了酸催化反应和碱催化反应的活化能，其与模型酯乙酸乙酯水解的活化能几乎相同。发现III的C-1游离酸的竞争酸催化反应比III的水解反应慢约10倍。
