Mahajani S S, Kulkarni R D
Int Arch Allergy Appl Immunol. 1977;53(2):137-44. doi: 10.1159/000231744.
Four weeks pretreatment with disodium cromoglycate (DSCG) and the powdered roots of the herb Picrorhiza kurroa, Benth, rendered guinea pigs less sensitive to histamine when compared with appropriate controls. The bronchodilator effects of isoprenaline and adrenaline were found to be markedly enhanced. The severity and duration of the allergic bronchospasm was significantly less in animals pretreated with the two drugs. Furthermore, the total histamine content of the lung tissue in animals pretreated with DSCG and P. kurroa was significantly less than that in the untreated controls. The pretreatment was also found to exhibit inhibitory effect on the immunological release of histamine and SRS-A from chopped lungs.
与适当的对照组相比，用色甘酸钠（DSCG）和胡黄连（Picrorhiza kurroa, Benth）的粉末状根进行四周预处理，使豚鼠对组胺的敏感性降低。发现异丙肾上腺素和肾上腺素的支气管扩张作用明显增强。在用这两种药物预处理的动物中，过敏性支气管痉挛的严重程度和持续时间明显减轻。此外，用DSCG和胡黄连预处理的动物肺组织中的总组胺含量明显低于未处理的对照组。还发现预处理对切碎的肺组织中组胺和慢反应物质A的免疫释放具有抑制作用。
