Suzuki K T, Ohnuki R, Yaguchi K, Yamada Y K
J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):727-37. doi: 10.1080/15287398309530380.
Cadmium was injected sc into female Wistar rats at a dose of 3.0 mg Cd/kg body weight, 4 times a week for 1, 2, 3, 4, 5, and 6 wk. Concentrations of cadmium in the spleen and pancreas were determined, together with essential metals, by inductively coupled plasma-atomic emission spectrometry. Cadmium in both tissues increased even after maximum concentration was attained in the liver. Contents of zinc, calcium, and magnesium in the spleen increased with splenomegaly, while content of iron decreased. Concentrations of calcium, magnesium, and iron decreased in the pancreas, while concentration of zinc showed a transitory increase. Cadmium in the spleen and pancreas supernatants was mostly bound to metallothionein, and metallothionein in the pancreas was highly susceptible to oxidation reaction. The spleen and pancreas were histologically less affected by cadmium loading compared to the liver and kidney, and the pancreas showed only slight alterations after injections for 5 and 6 wk.
将镉以3.0毫克镉/千克体重的剂量皮下注射到雌性Wistar大鼠体内，每周4次，持续1、2、3、4、5和6周。通过电感耦合等离子体原子发射光谱法测定脾脏和胰腺中镉的浓度以及必需金属的浓度。即使肝脏中达到最大浓度后，两种组织中的镉含量仍会增加。脾脏肿大时，脾脏中锌、钙和镁的含量增加，而铁的含量降低。胰腺中钙、镁和铁的浓度降低，而锌的浓度则短暂升高。脾脏和胰腺上清液中的镉大多与金属硫蛋白结合，并且胰腺中的金属硫蛋白极易发生氧化反应。与肝脏和肾脏相比，脾脏和胰腺在组织学上受镉负荷的影响较小，并且在注射5周和6周后，胰腺仅表现出轻微变化。
