Marinone G, Colle R, Mombelloni P
Minerva Med. 1978 Apr 14;69(18):1255-61.
A chemotherapeutic combination associating vincristine, adriamycin, procarbazine and prednisone (VAPP) was evaluated in Hodgkin's disease. Subjects were either far advanced cases or relapsing after MOPP and/or radiation therapy. 50 cases were evaluable. After 6 months of treatment 80% of the cases achieved a complete remission. After 30 months 87% of the patients still survive and 60% were still in complete remission. The good tolerance of this chemotherapeutic combination and the results described above, suggest that VAPP may be useful in all cases when MOPP is not well tolerated or is not active.
对一种联合使用长春新碱、阿霉素、丙卡巴肼和强的松（VAPP）的化疗方案在霍奇金病中的疗效进行了评估。研究对象为晚期病例或在接受MOPP方案和/或放射治疗后复发的患者。50例患者可进行评估。治疗6个月后，80%的病例实现了完全缓解。30个月后，87%的患者仍存活，60%仍处于完全缓解状态。这种化疗方案良好的耐受性以及上述结果表明，当MOPP方案耐受性不佳或无效时，VAPP方案可能对所有病例都有用。
