Brenner H R, Meier T, Widmer B
Nature. 1983;305(5934):536-7. doi: 10.1038/305536a0.
The formation of a motor endplate is characterized by a complex series of changes in the properties of the subsynaptic acetylcholine receptors (AChRs). Among the last changes to occur are the shortening of the apparent mean open time of their ion channels from about 4 to 1 ms and an increase in the single-channel conductance. This conversion of channel gating at the endplate seems to be induced by the motor neurone. We report here that fast channel gating also develops at nerve-free endplate sites of fibres that had been denervated while gating was still slow. At such sites, junctional folds will develop in the absence of the nerve terminal. Although the conversion of channel gating and the formation of junctional folds are late events in endplate development, the neural signals inducing these changes must therefore act at the earliest stages of junctional development.
运动终板的形成特点是突触后乙酰胆碱受体（AChRs）特性发生一系列复杂变化。其中最后发生的变化包括其离子通道的表观平均开放时间从约4毫秒缩短至1毫秒，以及单通道电导增加。终板处通道门控的这种转变似乎是由运动神经元诱导的。我们在此报告，在门控仍缓慢时已去神经支配的纤维的无神经终板部位也会出现快速通道门控。在这些部位，即使没有神经末梢也会形成突触褶。尽管通道门控的转变和突触褶的形成是终板发育中的后期事件，但诱导这些变化的神经信号必定在突触发育的最早阶段就起作用。
