Baer U, Souchon R, Bauknecht K J, Winter S
Strahlentherapie. 1983 Aug;159(8):474-82.
With regard to the permanent increase of perioperative irradiations in case of colorectal tumors, the possible influence of irradiation on the healing of anastomoses has been investigated. 230 rats were submitted to an irradiation of the rectosigmoidal region corresponding to the therapeutic method employed in human patients (focal dose of 50 Gy, in fractions of 4 x 2 Gy per week, interval of three weeks without irradiation). Rectosigmoidal anastomoses were performed one day, four weeks, eight weeks, and four months after the irradiation. The increase of connective tissue which is decisive for the stability of the anastomosis and which can be additionally induced by irradiation, was determined 3, 7, 14 and 21 days after the operation by identification of the hydroxyproline concentration within the anastomotic region. A comparison with nonirradiated animals shows that irradiation induces an additional formation of new connective tissue which becomes more intensive as the time interval since the finishing of irradiation is longer.
关于结直肠癌患者围手术期照射剂量的持续增加，已对照射对吻合口愈合的可能影响进行了研究。230只大鼠接受了直肠乙状结肠区域的照射，照射方式与人类患者所采用的治疗方法一致（局部剂量为50 Gy，每周分4次，每次2 Gy，照射间隔三周）。在照射后1天、4周、8周和4个月进行直肠乙状结肠吻合术。通过测定吻合区域内羟脯氨酸浓度，在术后3天、7天、14天和21天确定对吻合口稳定性起决定性作用且可因照射而额外诱导产生的结缔组织的增加情况。与未接受照射的动物相比，结果表明照射会额外诱导新结缔组织的形成，且随着照射结束后的时间间隔延长，这种诱导作用会更强。
