Szarmach H, Małyszko E, Wroński A
Z Hautkr. 1983 Aug 15;58(16):1183-90.
The purpose of these examinations was an attempt to elucidate the influence of some cytostatic preparations (Fluorouracil, Triaziquone (Treminon), Mechlorethaminee Oxide Hydrochloride (Mitomen), Methotroxate, Mitomycins, Cyclophosphamide (Endoxan), Mechlorethamin (Nitrogranulogen) and antibiotics (Penicillin, Streptomycin, Aureomycin, Nystatin) on formation of the multinuclear forms of Trichomonas under the conditions of culture on artificial medium and to investigate the cidal and static effects of chosen cytostatics and antibiotics of different species of Trichomonas in vitro. It was found that Mechlorethamine (Nitrogranulogen) and Mitomycins have distinct influence on formation of the multinuclear forms of Trichomonas in culture. Similar effects were observed in the antibiotic group with aureomycin only if applied pure or combined with other antibiotic drugs. In addition, it was shown that Triaziquone (Treminon) exerts the strongest effects on the examined species of Trichomonas.
这些检查的目的是试图阐明某些细胞抑制剂制剂（氟尿嘧啶、三嗪醌（曲米诺）、盐酸氮芥氧化物（米托明）、甲氨蝶呤、丝裂霉素、环磷酰胺（癌得星）、氮芥（硝颗粒原））和抗生素（青霉素、链霉素、金霉素、制霉菌素）在人工培养基培养条件下对多核型阴道毛滴虫形成的影响，并研究所选细胞抑制剂和抗生素对不同种阴道毛滴虫的体外杀菌和抑菌作用。结果发现，氮芥（硝颗粒原）和丝裂霉素对培养中多核型阴道毛滴虫的形成有明显影响。在抗生素组中，仅当单独使用或与其他抗生素药物联合使用金霉素时，才观察到类似效果。此外，还表明三嗪醌（曲米诺）对所检查的阴道毛滴虫种发挥最强作用。
