Bogolepov N N, Burd G S, Rumiantseva S A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(8):1137-42.
Experiments on 78 albino rats with ligated common carotid arteries were carried out to study the effect of a barbiturate agent (barbamil) administered in a dose of 150 mg/kg of animal body weight on cerebral capillary circulation at different terms of ischemia (1, 3 hours, 1, 3, 7, 14 days). The findings obtained during follow-up point to a beneficial effect of the barbiturate on the structures of the capillary wall (endotheliocytes, pericytes, basal membrane). Furthermore, the drug appears to maintain the capillary lumen and the normal level of capillary permeability, which contributes to the improvement of microcirculation in ischemia. The paper also describes some ultrastructural mechanisms of the decrease and stabilization of the cerebral capillary blood flow under the barbiturate impact due to endothelial synapses blockade, inhibition of vasoconstrictive mechanisms and stabilization of the membrane structures of the capillary network.
对78只结扎颈总动脉的白化大鼠进行了实验，以研究按动物体重150毫克/千克的剂量给予巴比妥酸盐制剂（巴比妥）在不同缺血期（1、3小时，1、3、7、14天）对脑毛细血管循环的影响。随访期间获得的结果表明，巴比妥酸盐对毛细血管壁结构（内皮细胞、周细胞、基底膜）具有有益作用。此外，该药物似乎能维持毛细血管腔和毛细血管通透性的正常水平，这有助于改善缺血时的微循环。本文还描述了在巴比妥酸盐作用下，由于内皮突触阻断、血管收缩机制抑制以及毛细血管网络膜结构稳定，脑毛细血管血流减少和稳定的一些超微结构机制。
