屏障饲养的Fischer 344雄性大鼠衰老过程中的病理变化。
Pathological changes during aging in barrier-reared Fischer 344 male rats.
作者信息
Coleman G L, Barthold W, Osbaldiston G W, Foster S J, Jonas A M
出版信息
J Gerontol. 1977 May;32(3):258-78. doi: 10.1093/geronj/32.3.258.
Abstract
Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age, while alpha-1 globulin and cholesterol increased.
摘要
对144只4至33月龄的雄性Fischer大鼠进行了病理学、微生物学及选定血清化学指标的评估。这些大鼠在屏障条件下饲养和维持，在整个研究过程中成功排除了主要传染病原体的引入，包括肺支原体。发现了多种病理学情况并进行了列表统计，许多病变的严重程度和发病率随年龄增长而增加。肾脏疾病严重程度与年龄增长高度相关，同时α-1球蛋白和胆固醇升高。
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