匹西那多（LY 150720）与哌替啶和安慰剂相比用于缓解剖宫产术后疼痛：一项随机双盲研究。

Picenadol (LY 150720) compared with meperidine and placebo for relief of post-cesarean section pain: a randomized double-blind study.

作者信息

Sherline D M

出版信息

Am J Obstet Gynecol. 1983 Oct 15;147(4):404-6. doi: 10.1016/s0002-9378(16)32234-7.

Abstract

Picenadol (LY 150720) is a racemic mixture of an N-methyl-4-phenylpiperidine derivative, with agonist-antagonist opiate properties. Preclinical animal pharmacology and toxicology studies demonstrated analgesic activity and a low order of toxicity. Clinical pharmacology studies have demonstrated its safety in man. Hospitalized post-cesarean section patients with postoperative pain were blindly given an intramuscular dose of picenadol, 25 mg, meperidine, 100 mg, or placebo. Analgesia and side effects of picenadol and meperidine were similar.

摘要

匹西那多（LY 150720）是一种N-甲基-4-苯基哌啶衍生物的外消旋混合物，具有激动-拮抗型阿片样物质特性。临床前动物药理学和毒理学研究证明了其镇痛活性和低毒性。临床药理学研究证明了其在人体中的安全性。对剖宫产术后住院且有术后疼痛的患者，分别盲法给予肌肉注射25毫克匹西那多、100毫克哌替啶或安慰剂。匹西那多和哌替啶的镇痛效果及副作用相似。