Luton J P, Vidal-Trecan G, Mouveroux F, Bricaire H
Ann Med Interne (Paris). 1983;134(3):203-8.
Over two thirds of patients with Cushing's disease suffer from hypertension. An analysis of 155 patients with Cushing's syndrome was undertaken to study its incidence and effects, and the biological profile and prognosis of the patients. The renin-angiotensin-aldosterone system was given particular attention in 5 patients. Serum angiotensin was raised and a positive correlation was observed with the serum cortisol. Serum aldosterone did not respond as normal to the usual stimuli and the normal plasma renin activity did not vary during the 24 hour period. The physiopathogenesis of hypertension in Cushing's disease is still not fully understood, especially with regard to the mode of action of the hypercortisolism, the essential factor. A mineralocorticoid type of behaviour, especially in the severe forms, may be associated with that of the ACTH-dependent precursors, a permissive action on certain pressor substances, the increase in secretion of angiotensin in parallel to that of the cortisol and finally, the increase in the risk factors probably play a role. The outcome of the hypertension after specific treatment of Cushing's disease is usually favourable. However, hypertension persists in a third of cases.
超过三分之二的库欣病患者患有高血压。对155例库欣综合征患者进行了分析，以研究其发病率、影响以及患者的生物学特征和预后。对其中5例患者特别关注了肾素-血管紧张素-醛固酮系统。血清血管紧张素升高，且与血清皮质醇呈正相关。血清醛固酮对通常的刺激无正常反应，正常血浆肾素活性在24小时内无变化。库欣病高血压的发病机制仍未完全明了，尤其是关于高皮质醇血症这一关键因素的作用方式。盐皮质激素样作用，特别是在严重形式中，可能与促肾上腺皮质激素依赖性前体的作用、对某些升压物质的允许作用、血管紧张素分泌与皮质醇分泌平行增加以及最终危险因素增加有关，这些可能都起了作用。库欣病经特异性治疗后高血压的预后通常良好。然而，三分之一的病例中高血压仍会持续。
