一名婴儿的自身免疫性中性粒细胞减少症。
Auto-immune neutropenia in an infant.
作者信息
Thompson D S, Stableforth P, Darlow B, Brazier D M
出版信息
Postgrad Med J. 1978 Apr;54(630):278-80. doi: 10.1136/pgmj.54.630.278.
Abstract
A case of neutropenia in an infant is described, associated with repeated minor infections which responded to treatment with antibiotics. A granulocyte agglutinin was detected in the serum. Following treatment with prednisolone the neutropenia remitted, the antibody disappeared and the infections ceased. Treatment was discontinued after three months and the child remained well five months later. Reports of similar cases are reviewed and the significance of the antibody discussed.
摘要
本文描述了一例婴儿中性粒细胞减少症，伴有反复的轻度感染，经抗生素治疗后有反应。在血清中检测到一种粒细胞凝集素。用泼尼松龙治疗后，中性粒细胞减少症缓解，抗体消失，感染停止。三个月后停止治疗，五个月后患儿情况良好。本文回顾了类似病例的报告并讨论了抗体的意义。
相似文献
1
Auto-immune neutropenia in an infant.
Postgrad Med J. 1978 Apr;54(630):278-80. doi: 10.1136/pgmj.54.630.278.
2
Chronic autoimmune neutropenia due to anti-NA1 antibody.
Vox Sang. 1979;36(1):9-12. doi: 10.1111/j.1423-0410.1979.tb04391.x.
3
Autoimmune neutropenia in an infant.
J Pediatr. 1975 Aug;87(2):251-4. doi: 10.1016/s0022-3476(75)80596-8.
4
Chronic idiopathic and secondary neutropenia: clinical and serological investigations.
Br J Haematol. 1986 May;63(1):161-71. doi: 10.1111/j.1365-2141.1986.tb07506.x.
5
Group-specific auto-immune antibodies directed to granulocytes as a cause of chronic benign neutropenia in infants.
Acta Haematol. 1982;68(1):20-7. doi: 10.1159/000206943.
6
Anti-granulocyte opsonic activity and autoimmune neutropenia.
Br J Haematol. 1986 Jul;63(3):581-9. doi: 10.1111/j.1365-2141.1986.tb07536.x.
7
Acquired agranulocytosis with granulocyte specific cytotoxic autoantibody.
Am J Med. 1979 May;66(5):862-6. doi: 10.1016/0002-9343(79)91138-0.
8
Autoimmune neutropenia.
Nihon Ketsueki Gakkai Zasshi. 1985 Dec;48(8):1753-63.
9
A comparison of methods for detecting leukocyte antibodies in autoimmune neutropenia.
Transfusion. 1981 Sep-Oct;21(5):483-92. doi: 10.1046/j.1537-2995.1981.21582040808.x.
10
[Immune granulocytopenia in children].
Klin Padiatr. 1989 Nov-Dec;201(6):431-5. doi: 10.1055/s-2008-1026742.
本文引用的文献
1
The incidence and significance of complete and incomplete white cell antibodies with special reference to the use of the Coombs consumption test.
Vox Sang. 1958 May;3(3):203-23. doi: 10.1111/j.1423-0410.1958.tb03614.x.
2
Isoimmune neonatal neutropenia.
J Pediatr. 1972 May;80(5):783-7. doi: 10.1016/s0022-3476(72)80131-8.
3
Effects of anti-human neutrophil antibodies in vitro. Quantitative studies.
J Clin Invest. 1974 Jun;53(6):1534-45. doi: 10.1172/JCI107704.
4
Cytotoxic antibodies against leucocytes.
Vox Sang. 1966 May-Jun;11(3):334-44.
5
Neutrophil-specific antigens: immunology and clinical significance.
Semin Hematol. 1974 Jul;11(3):281-90.
6
Leucocyte function in a case of chronic benign neutropenia of infancy associated with circulating leucoagglutinins.
Br J Haematol. 1976 Mar;32(3):451-7. doi: 10.1111/j.1365-2141.1976.tb00948.x.
7
Autoimmune neutropenia.
N Engl J Med. 1975 Oct 9;293(15):748-53. doi: 10.1056/NEJM197510092931505.
8
Chronic autoimmune neutropenia due to anti-NA2 antibody.
N Engl J Med. 1975 Oct 9;293(15):744-7. doi: 10.1056/NEJM197510092931504.
9
Autoimmune neutropenia in an infant.
J Pediatr. 1975 Aug;87(2):251-4. doi: 10.1016/s0022-3476(75)80596-8.
10
Quantitative determination of antibody in idiopathic thrombocytopenic purpura. Correlation of serum and platelet-bound antibody with clinical response.
N Engl J Med. 1975 Jan 30;292(5):230-6. doi: 10.1056/NEJM197501302920503.
Zotero 插件