Valbonesi M, Campelli A, Marazzi M G, Cottafava F, Jannuzzi C
Vox Sang. 1979;36(1):9-12. doi: 10.1111/j.1423-0410.1979.tb04391.x.
A 12-month-old child neutropenic since the age of 8 months, was referred to our institute for a sepsis from Candida albicans. On exploring the cause of neutropenia, an anti-NA1 antibody could be detected in the patient's serum. This antibody seemed to be responsible for the neutropenia because the child's PMN type was NA1+. The reactivity of the autoantibody with the patient's own granulocytes was confirmed by direct and indirect immunofluorescence studies performed on blood and marrow cells. A reduced number of T lymphocytes with poor PHA responsivity has been interpreted as the possible cause of the autoimmune disease. Steroid therapy did not cure the neutropenia but the child's general condition improved.
一名自8个月大起就患有中性粒细胞减少症的12个月大儿童，因白色念珠菌败血症被转诊至我院。在探究中性粒细胞减少症的病因时，在患者血清中检测到了一种抗NA1抗体。这种抗体似乎是中性粒细胞减少症的病因，因为患儿的中性粒细胞类型为NA1+。通过对血液和骨髓细胞进行直接和间接免疫荧光研究，证实了自身抗体与患者自身粒细胞的反应性。T淋巴细胞数量减少且对PHA反应性差被认为是自身免疫性疾病的可能病因。类固醇治疗未能治愈中性粒细胞减少症，但患儿的总体状况有所改善。
