Nilsson S, Schwartz B D, Waxdal M, Green E, Cullen S E, Mann D L
J Immunol. 1977 Apr;118(4):1271-4.
Alloantigens specific for human B lymphocytes can be identified with selected antisera. These antigens have similarities to murine Ia antigens in that they are found on human B lymphocytes and are controlled by genes linked to genes controlling HLA. Chronic lymphocytic leukemia cells bearing B cell antigens were labeled with 3H leucine and the membrane components reacting with the B cell antisera isolated by immunoprecipitation. These membrane components had m.w. of 33,000 and 24,000 daltons similar to the murine Ia antigens. The results complete the homology of murine Ia and human B cell alloantigens.
可通过选用的抗血清识别出针对人类B淋巴细胞的同种异体抗原。这些抗原与鼠类Ia抗原有相似之处，因为它们存在于人类B淋巴细胞上，并由与控制HLA的基因相连的基因所控制。携带B细胞抗原的慢性淋巴细胞白血病细胞用³H亮氨酸进行标记，然后通过免疫沉淀分离出与B细胞抗血清发生反应的膜成分。这些膜成分的分子量为33,000和24,000道尔顿，与鼠类Ia抗原相似。这些结果完善了鼠类Ia抗原与人类B细胞同种异体抗原的同源性。
