来自人胎盘的胰岛素受体相关蛋白激酶使肌动蛋白磷酸化的证据。
Evidence for phosphorylation of actin by the insulin receptor-associated protein kinase from human placenta.
作者信息
Machicao F, Urumow T, Wieland O H
出版信息
FEBS Lett. 1983 Oct 31;163(1):76-80. doi: 10.1016/0014-5793(83)81167-3.
PMID:6628693
Abstract
A purified preparation of rabbit muscle actin (43-kDa protein) is phosphorylated at tyrosine residues when incubated with solubilized insulin receptor from human placenta. Phosphorylation of the 95-kDa receptor subunit and of 43-kDa protein is stimulated by insulin and vanadate, respectively; however, the mode of action of the two agents is distinguishable.
摘要
将兔肌肉肌动蛋白（43 kDa蛋白）的纯化制剂与人胎盘的可溶性胰岛素受体一起孵育时，酪氨酸残基会发生磷酸化。胰岛素和钒酸盐分别刺激95 kDa受体亚基和43 kDa蛋白的磷酸化；然而，这两种物质的作用方式是有区别的。
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