Whitaker T B, Dickens J W
J Assoc Off Anal Chem. 1983 Sep;66(5):1055-8.
A computer model that accounts for sampling and analytical variability was developed to simulate the aflatoxin testing program administered by the North Carolina Department of Agriculture (NCDA) to regulate aflatoxin in corn meal. Monte Carlo solution techniques were employed to account for conditional probabilities that rise from multiple samples being used in the testing program. The NCDA testing program was then evaluated by applying the computer model to a hypothetical group of 1000 corn meal lots with the same distribution of aflatoxin concentrations as was observed among aflatoxin assays made by NCDA on commercial lots of corn meal from 1977 to 1980. The average of the 1000 lots assayed was 17.7 parts per billion (ppb). The model predicted that 79.5% of the lots would be accepted and 20.5% of the lots would be rejected by the NCDA testing program. The accepted and rejected lots contained an average of 5.7 and 64.2 ppb aflatoxin, respectively. The testing program accepted 7.3% of the lots with more than 20 ppb aflatoxin (consumers' risk) and rejected 1.0% of the lots with 20 ppb or less (processors' risk). A correct decision was made 94% of the time.
开发了一个考虑采样和分析变异性的计算机模型,以模拟北卡罗来纳州农业部(NCDA)实施的黄曲霉毒素检测计划,该计划用于监管玉米粉中的黄曲霉毒素。采用蒙特卡罗求解技术来考虑检测计划中使用多个样本所产生的条件概率。然后,通过将计算机模型应用于假设的1000个玉米粉批次,对NCDA检测计划进行评估,这些批次的黄曲霉毒素浓度分布与1977年至1980年NCDA对商业玉米粉批次进行的黄曲霉毒素检测中观察到的分布相同。所检测的1000个批次的平均值为十亿分之17.7(ppb)。该模型预测,NCDA检测计划将接受79.5%的批次,拒绝20.5%的批次。被接受和被拒绝的批次中黄曲霉毒素的平均含量分别为5.7 ppb和64.2 ppb。该检测计划接受了7.3%黄曲霉毒素含量超过20 ppb的批次(消费者风险),并拒绝了1.0%黄曲霉毒素含量为20 ppb或更低的批次(加工商风险)。94%的情况下做出了正确的决策。