Noland E A, McCauley P T, Bull R J
J Toxicol Environ Health. 1983 Jul;12(1):89-98. doi: 10.1080/15287398309530409.
Dimethyltin dichloride (DMDC) is commonly used as a stabilizer in PVC pipe used for transport of potable water. Learning deficiencies have been observed postnatally in pups from DMDC-treated dams. Studies were conducted with female Sprague-Dawley rats to determine whether DMDC was absorbed by the dam and transferred across the placenta to fetal blood and brain tissue. This was accomplished in three phases: (1) a comparison of absorption of organic and inorganic tin from drinking water, (2) a comparison of prenatal and postnatal levels of tin in the pups in cross-fostering studies, and (3) a [14C]dimethyltin dichloride tracer study to determine whether organic tin passed to the pup intact. Major findings include: (1) DMDC is absorbed in the gastrointestinal tract of the dam much more rapidly than Sn2+; (2) the more rapid absorption of DMDC results in higher concentration of tin in fetal blood and brain; and (3) in fetuses that receive tin as DMDC, both tin and the methyl carbon are absorbed by the dam and transferred to the blood and brain of the fetuses.
二氯二甲基锡（DMDC）通常用作输送饮用水的聚氯乙烯（PVC）管中的稳定剂。在产后观察到，用DMDC处理过的母鼠所产幼崽存在学习缺陷。对雌性斯普拉格-道利大鼠进行了研究，以确定DMDC是否会被母鼠吸收，并通过胎盘转移到胎儿的血液和脑组织中。这一研究分三个阶段完成：（1）比较从饮用水中吸收有机锡和无机锡的情况；（2）在交叉寄养研究中比较幼崽产前和产后的锡含量；（3）进行一项[14C]二氯二甲基锡示踪研究，以确定有机锡是否完整地传递给幼崽。主要研究结果包括：（1）DMDC在母鼠胃肠道中的吸收速度比Sn2+快得多；（2）DMDC的更快吸收导致胎儿血液和大脑中的锡浓度更高；（3）在以DMDC形式摄入锡的胎儿中，锡和甲基碳均被母鼠吸收，并转移到胎儿的血液和大脑中。
