Resistance of a substrain of Wistar rats to salt hypertension.

Male rats of the Wistar substrain, in which 2/3 nephrectomy was performed, did not develop hypertension when placed on a high salt intake, while rats of the Long-Evans substrain become hypertensive under the same conditions. The described substrain of Wistar rats represents a useful experimental model for studying the mechanism of resistance to the hypertensive stimulus of salt overload.