Coruzzi G, Poli E, Adami M, Bertaccini G, Starcich B
Pharmacol Res Commun. 1983 Sep;15(8):719-34. doi: 10.1016/s0031-6989(83)80002-2.
Angiotensin II was tested for its activity on rabbit aorta, lower esophageal sphincter (LES) from the rat, rat gastric fundus and rat colon. The peptide had a powerful stimulatory effect on vascular and extravascular smooth muscle beginning from concentrations of 10(-10) M. Its effect was antagonized by saralasin which acted in the different preparations to approximately the same extent: active concentrations of saralasin varied from 10(-8) M to 10(-7) M. The activity of angiotensin on the rabbit aorta appeared to be a direct one on its specific receptors. A mixed action connected with stimulation of adrenergic alpha receptors was observed in the rat LES, whereas an interference of the prostaglandin system was pointed out in the rat fundus and the rat colon. The circumstance of a similar sensitivity of the various tissues to the stimulatory effect of angiotensin and a similar degree of antagonism induced by saralasin tends to minimize the hypothesis of different subtypes of angiotensin receptors at least under the conditions of the present investigation.
对血管紧张素II在兔主动脉、大鼠下食管括约肌（LES）、大鼠胃底和大鼠结肠上的活性进行了测试。该肽从10^(-10) M的浓度开始就对血管和平滑肌产生强大的刺激作用。其作用可被沙拉新拮抗，沙拉新在不同制剂中的作用程度大致相同：沙拉新的活性浓度从10^(-8) M到10^(-7) M不等。血管紧张素对兔主动脉的活性似乎是直接作用于其特异性受体。在大鼠LES中观察到与刺激肾上腺素能α受体相关的混合作用，而在大鼠胃底和大鼠结肠中指出了前列腺素系统的干扰。各种组织对血管紧张素刺激作用的相似敏感性以及沙拉新诱导的相似拮抗程度这一情况，倾向于至少在本研究条件下尽量减少血管紧张素受体不同亚型的假说。
