泛硫乙胺及其代谢产物对大鼠肝脏线粒体脂肪酸氧化的影响。
Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
作者信息
Morisaki N, Matsuoka N, Saito Y, Kumagai A
出版信息
Tohoku J Exp Med. 1983 Sep;141(1):33-9. doi: 10.1620/tjem.141.33.
PMID:6636147
Abstract
The mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)disulfide] on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4'-phosphopantetheine activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine, acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.
摘要
在大鼠肝脏线粒体中研究了泛硫乙胺[D-双-(N-泛酰基-β-氨基乙基)二硫化物]对脂肪酸氧化的激活作用机制。泛硫乙胺、泛硫醇和4'-磷酸泛硫醇在不同程度上激活了脂肪酸氧化的三个步骤，即酰基辅酶A合成酶、肉碱、酰基转移酶和线粒体内氧化。尽管它们的作用可能部分归因于由它们衍生而来的辅酶A，但它们也有特定的作用。
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