氟尿嘧啶对兔视网膜的毒性作用。

Toxic effect of fluorouracil on the rabbit retina.

作者信息

Nao-i N, Honda Y

出版信息

Am J Ophthalmol. 1983 Nov;96(5):641-3. doi: 10.1016/s0002-9394(14)73422-1.

Abstract

We conducted electrophysiologic tests of the toxic effects of fluorouracil on 26 albino rabbit eyes. Fluorouracil concentrations of 10(-7) g/ml, 10(-6) g/ml, and 10(-5) g/ml produced no significant changes in the b-wave amplitudes of the electroretinogram. A concentration of 10(-4) g/ml, however, reduced the b-wave amplitude to 62% +/- 7.3% of the original value after 60 minutes. A concentration of 10(-3) g/ml decreased the value even further, to 41% +/- 12% of the original value. At this concentration the a-wave appeared to be enhanced, probably because the ascending phase of the b-wave was delayed. A concentration of 5 X 10(-3 g/ml resulted in disappearance of the b-wave within approximately three minutes, but removal of the test solution and replacement with a fluorouracil-free medium produced recovery of the b-wave amplitude to 89% +/- 9.9% of the original value within 55 minutes.

摘要

我们对26只白化兔眼进行了氟尿嘧啶毒性作用的电生理测试。浓度为10(-7) g/ml、10(-6) g/ml和10(-5) g/ml的氟尿嘧啶对视网膜电图的b波振幅未产生显著变化。然而，浓度为10(-4) g/ml时，60分钟后b波振幅降至原始值的62%±7.3%。浓度为10(-3) g/ml时，该值进一步降低，降至原始值的41%±12%。在此浓度下，a波似乎增强，可能是因为b波的上升相延迟。浓度为5×10(-3) g/ml时，b波在大约三分钟内消失，但去除测试溶液并替换为无氟尿嘧啶的培养基后，b波振幅在55分钟内恢复至原始值的89%±9.9%。