Strasberg B, Prechel D, Bauman J, Coelho A, Swiryn S, Bauernfeind R, Rosen K M
Arch Intern Med. 1983 Nov;143(11):2131-3.
Aprindine hydrochloride is an antiarrhythmic agent presently undergoing clinical trials in the United States. Because of the narrow therapeutic-toxic ratio observed for aprindine, the long-term follow-up of these patients is important in determining the potential clinical effectiveness of this drug. In this report we examine our experience with 30 patients with drug-resistant arrhythmias who were discharged receiving aprindine and who were followed up for a mean period of 25 months.
盐酸阿普林定是一种抗心律失常药物，目前正在美国进行临床试验。由于观察到阿普林定的治疗毒性比很窄，对这些患者进行长期随访对于确定该药物的潜在临床疗效很重要。在本报告中，我们研究了30例耐药性心律失常患者的情况，这些患者出院时接受阿普林定治疗，并平均随访了25个月。
