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脑腱黄瘤病中5β-胆甾烷-3α,7α,12α,23β-四醇、5β-胆甾烷-3α,7α,12α,24α-四醇和5β-胆甾烷-3α,7α,12α,24β-四醇的鉴定

Identifications of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 23 beta-tetrol, 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 alpha-tetrol, and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 beta-tetrol in cerebrotendinous xanthomatosis.

作者信息

Yasuhara M, Kuramoto T, Hoshita T, Itoga E, Kito S

出版信息

Steroids. 1978 Mar;31(3):333-45. doi: 10.1016/0039-128x(78)90047-8.

DOI:10.1016/0039-128x(78)90047-8
PMID:663972
Abstract

The bile alcohols present in the feces of a patient with cerebrotendinous xanthomatosis were studied. Three bile alcohols which are different from any known natural bile alcohol were isolated as minor components of the fecal bile alcohol fraction. The structures of these compounds were established as 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 23 beta-tetrol, 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 alpha-tetrol, and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 beta-tetrol by comparison with synthetic samples.

摘要

对脑腱性黄瘤病患者粪便中的胆汁醇进行了研究。从粪便胆汁醇组分的次要成分中分离出三种与任何已知天然胆汁醇不同的胆汁醇。通过与合成样品比较,确定这些化合物的结构为5β-胆甾烷-3α,7α,12α,23β-四醇、5β-胆甾烷-3α,7α,12α,24α-四醇和5β-胆甾烷-3α,7α,12α,24β-四醇。

相似文献

1
Identifications of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 23 beta-tetrol, 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 alpha-tetrol, and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 24 beta-tetrol in cerebrotendinous xanthomatosis.脑腱黄瘤病中5β-胆甾烷-3α,7α,12α,23β-四醇、5β-胆甾烷-3α,7α,12α,24α-四醇和5β-胆甾烷-3α,7α,12α,24β-四醇的鉴定
Steroids. 1978 Mar;31(3):333-45. doi: 10.1016/0039-128x(78)90047-8.
2
Bile alcohol profiles in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis.脑腱黄瘤病患者胆汁、尿液和粪便中的胆汁醇谱。
J Biochem. 1986 Feb;99(2):477-83. doi: 10.1093/oxfordjournals.jbchem.a135502.
3
Determination of the glucurono-conjugated position in bile alcohol glucuronides present in a patient with cerebrotendinous xanthomatosis.
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4
Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis.脑腱黄瘤病患者胆汁中胆汁醇葡萄糖醛酸苷的出现情况。
J Lipid Res. 1980 Nov;21(8):1015-21.
5
Absolute configuration at carbon 23 of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,23,25-pentol excreted by patients with cerebrotendinous xanthomatosis.脑腱黄瘤病患者排泄的5β-胆甾烷-3α,7α,12α,23,25-戊醇中碳23的绝对构型。
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Increased plasma bile alcohol glucuronides in patients with cerebrotendinous xanthomatosis: effect of chenodeoxycholic acid.脑腱黄瘤病患者血浆胆汁醇葡萄糖醛酸苷水平升高:鹅去氧胆酸的作用
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7
Effect of chenodeoxycholic acid on biliary and urinary bile acids and bile alcohols in cerebrotendinous xanthomatosis; monitoring by high performance liquid chromatography.鹅去氧胆酸对脑腱黄瘤病患者胆汁及尿中胆汁酸和胆汁醇的影响;高效液相色谱法监测
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8
Identification of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 25, 26-pentol in cerebrotendinous xanthomatosis.脑腱黄瘤病中5β-胆甾烷-3α、7α、12α、25、26-戊醇的鉴定。
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9
Synthesis and structure of 26 (or 27)-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24S,25 xi-pentol isolated from the urine and feces of a patient with sitosterolemia and xanthomatosis.从患有谷甾醇血症和黄瘤病的患者尿液和粪便中分离出的26(或27)-降-5β-胆甾烷-3α,7α,12α,24S,25ξ-戊醇的合成与结构
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10
Bile alcohol glucuronides: regioselective O-glucuronidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol and 24-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol.胆汁醇葡糖醛酸苷:5β-胆甾烷-3α,7α,12α,25-四醇和24-降-5β-胆甾烷-3α,7α,12α,25-四醇的区域选择性O-葡糖醛酸化
Carbohydr Res. 1993 Feb 24;240:133-42. doi: 10.1016/0008-6215(93)84178-9.