Owen F, Poulter M, Waddington J L, Mashal R D, Crow T J
Brain Res. 1983 Nov 14;278(1-2):373-5. doi: 10.1016/0006-8993(83)90276-7.
In agreement with other workers we report increased [3H]R05-4864 binding in kainate-lesioned rat striatum. [3H]R05-4864 binding, a possible glial marker, was also increased in temporal cortex obtained post-mortem from patients with Alzheimer's disease. [3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss. It is suggested that the poor binding characteristics of [3H]R05-4864 in human brain samples may limit its usefulness in assessing gliosis.
与其他研究人员的结果一致，我们报告了在红藻氨酸损伤的大鼠纹状体中，[3H]R05 - 4864结合增加。[3H]R05 - 4864结合是一种可能的神经胶质标志物，在阿尔茨海默病患者死后获得的颞叶皮质中也有所增加。在这些脑样本中，[3H]氟硝西泮结合减少，这可能表明神经元细胞丢失。有人提出，[3H]R05 - 4864在人脑样本中较差的结合特性可能会限制其在评估神经胶质增生方面的用途。
