Le Fur G, Guilloux F, Uzan A
Clin Exp Hypertens A. 1983;5(9):1537-42. doi: 10.3109/10641968309069509.
The in vivo binding of [3H]spiperone was measured in discrete areas of the hypothalamus in 7, 9 and 16 weeks old spontaneously hypertensive rats (SHR) and age matched normotensive Wistar Kyoto (WKY) controls. The specific binding of [3H]spiperone was significantly higher in the four different hypothalamic regions (H1, H2, H3, H4) that we have tested in 7 or 9 weeks old SHR than in age matched WKY controls. At 16 weeks a significant increase was only present in H3. These results suggest that dopaminergic hypothalamic neurons might be implicated in the onset of hypertension in the rat.
在7周龄、9周龄和16周龄的自发性高血压大鼠（SHR）以及年龄匹配的正常血压Wistar Kyoto（WKY）对照大鼠的下丘脑离散区域中，测定了[3H]司哌罗宁的体内结合情况。在7周龄或9周龄的SHR中，我们测试的四个不同下丘脑区域（H1、H2、H3、H4）中，[3H]司哌罗宁的特异性结合显著高于年龄匹配的WKY对照。在16周龄时，仅H3区域出现显著增加。这些结果表明，多巴胺能下丘脑神经元可能与大鼠高血压的发病有关。
