Bertrand M E, Lablanche J M, Tilmant P Y, Thieuleux F A, Delforge M G, Chahine R A
Eur Heart J. 1983 Aug;4(8):532-5. doi: 10.1093/oxfordjournals.eurheartj.a061518.
Provocative tests for coronary spasm were performed in a group of 131 patients (124 men and 7 women) with recent (less than 6 weeks) transmural myocardial infarction. Coronary arteriography was performed 27 +/- 9 days after the onset of the infarction. The provocative test was performed using a single IV bolus of 0.4 mg of ergometrine. Aortic pressure, ECG and arteriograms of the two coronary vessels were repeated 3 and 5 min later. Provoked spasm was observed in 27 (21%) of the patients. In 13 (48%) the coronary spasm occurred in a vessel presumed to be responsible for the myocardial infarction, while it was observed in coronary artery unrelated to the area of the infarct in 14 (52% of the cases with spasm). Thus, this study demonstrates a high degree of reactivity of the coronary tree of patients with recent transmural myocardial infarction suggesting the likelihood of a role for spasm in the infarction process and offering some explanation for subsequent recurrent ischemic events.
对一组131例近期（不到6周）发生透壁性心肌梗死的患者（124例男性和7例女性）进行了冠状动脉痉挛激发试验。在梗死发作后27±9天进行冠状动脉造影。激发试验采用静脉推注0.4毫克麦角新碱。3分钟和5分钟后重复测量主动脉压力、心电图以及两支冠状动脉的血管造影。27例（21%）患者出现诱发性痉挛。其中13例（48%）冠状动脉痉挛发生在推测为心肌梗死责任血管的血管中，而在与梗死区域无关的冠状动脉中观察到痉挛的有14例（占痉挛病例的52%）。因此，本研究表明近期发生透壁性心肌梗死患者的冠状动脉树具有高度反应性，提示痉挛在梗死过程中可能起作用，并为随后的复发性缺血事件提供了一些解释。
