Modulation of isocitrate dehydrogenase activity in Acinetobacter calcoaceticus by acetate.

The addition of acetate to a culture of Acinetobacter calcoaceticus grown in medium containing limiting succinate as the sole carbon and energy source leads to an increase in the specific activity of isocitrate dehydrogenase. This is in contrast to similar studies with several other microorganisms in which acetate induces an ATP-dependent phosphorylation and concomitant decrease in the specific activity of this enzyme.