Wistedt B, Palmstierna T
J Clin Psychiatry. 1983 Oct;44(10):369-71.
A double-blind randomized investigation compared withdrawal (placebo) with continued use of long-acting neuroleptics (fluphenazine decanoate or flupenthixol decanoate) in 41 chronic schizophrenic outpatients. After 6 weeks there was a tendency toward higher depressive scores in the placebo group, a difference which became statistically significant (p less than .05) at week 24. These results do not support earlier observations that neuroleptic drugs cause depression. Further analyses of the data indicated that depressive symptomatology could be an early sign of relapse.
一项双盲随机研究对41名慢性精神分裂症门诊患者停用长效抗精神病药物（安慰剂）与继续使用长效抗精神病药物（癸酸氟奋乃静或癸酸氟哌噻吨）进行了比较。6周后，安慰剂组的抑郁评分有升高趋势，这一差异在第24周时具有统计学意义（p<0.05）。这些结果不支持早期关于抗精神病药物会导致抑郁的观察结果。对数据的进一步分析表明，抑郁症状可能是复发的早期迹象。
