Falconer I R, Vacek A T
J Endocrinol. 1983 Dec;99(3):369-77. doi: 10.1677/joe.0.0990369.
Hyperprolactinaemia in patients with chronic renal disease undergoing dialysis has prompted the investigation of the relative roles of liver and kidney in the degradation of prolactin. Male rabbits were acutely nephrectomized, and compared with intact animals with or without prolactin infusion. Prolactin degradation was followed after intravenous injection of 125I-labelled ovine prolactin. Measurements were made of peptide-bound 125I and 125I-labelled degradation products in plasma, liver, kidney, bile, urine and muscle and total thyroid radioactivity. A significant (P less than 0.01) reduction in the metabolic clearance rate of 125I-labelled prolactin was observed due to nephrectomy, with double the accumulation of 125I-labelled peptides in the livers in this group. Prolactin infusion of nephrectomized animals had a further and larger effect than nephrectomy alone on prolactin degradation. Metabolic clearance rate significantly (P less than 0.01) decreased from 5.5 ml/min per kg in nephrectomized rabbits to 0.8 ml/min per kg with prolactin infusion. The accumulation of 125I-labelled prolactin degradation products in the blood was significantly (P less than 0.01) lower in this group of animals and the amount of peptide-bound 125I in plasma at 60 min after 125I-labelled prolactin administration was significantly (P less than 0.01) higher. Liver degradation of prolactin in the absence of exogenous hormone appears to be sufficient to maintain an approximately normal half-life for prolactin in plasma (intact t 1/2 = 6.8 min; nephrectomized t 1/2 = 8.5 min).(ABSTRACT TRUNCATED AT 250 WORDS)
接受透析的慢性肾病患者出现高催乳素血症，这促使人们研究肝脏和肾脏在催乳素降解中的相对作用。对雄性兔子进行急性肾切除，并与输注或未输注催乳素的完整动物进行比较。静脉注射125I标记的羊催乳素后，追踪催乳素的降解情况。对血浆、肝脏、肾脏、胆汁、尿液和肌肉中的肽结合125I和125I标记的降解产物以及甲状腺总放射性进行了测量。由于肾切除，观察到125I标记催乳素的代谢清除率显著降低（P<0.01），该组动物肝脏中125I标记肽的积累量增加了一倍。对肾切除动物输注催乳素比单独肾切除对催乳素降解的影响更大且更显著。代谢清除率从肾切除兔子的5.5 ml/min per kg显著降低（P<0.01）至输注催乳素后的0.8 ml/min per kg。该组动物血液中125I标记催乳素降解产物的积累量显著降低（P<0.01），且在注射125I标记催乳素60分钟后血浆中肽结合125I的量显著升高（P<0.01）。在没有外源激素的情况下，肝脏对催乳素的降解似乎足以维持血浆中催乳素大致正常的半衰期（完整动物t1/2 = 6.8分钟；肾切除动物t1/2 = 8.5分钟）。（摘要截选至250字）
