Freedman R S, Gutterman J U, Wharton J T, Rutledge F N
J Biol Response Mod. 1983;2(2):133-8.
Human leukocyte interferon (IFN alpha) was administered to 15 patients with epithelial ovarian carcinoma after previous chemotherapy or therapeutic irradiation. One objective response was observed. Three patients had possible stable disease for up to 6 months, including two patients who were re-explored 6 months after commencing IFN alpha and one patient who was observed to have a less than 50% reduction in her tumor diameters. Three of seven patients demonstrated clinical responses to subsequent chemotherapy, indicating an absence of resistance to subsequent chemotherapy. Toxicity included the relatively mild symptoms of anorexia, lassitude, and diarrhea. Malabsorption was observed in one patient. Platelet depression and abnormal enzyme liver functions were also observed more frequently following IFN alpha. No life-threatening toxicity was observed.
对15例上皮性卵巢癌患者在先前化疗或放疗后给予人白细胞干扰素（IFNα）。观察到1例客观缓解。3例患者病情可能稳定达6个月，其中2例在开始使用IFNα6个月后再次接受探查，1例患者肿瘤直径缩小不到50%。7例患者中有3例对后续化疗有临床反应，表明对后续化疗无耐药性。毒性包括相对较轻的厌食、乏力和腹泻症状。1例患者出现吸收不良。使用IFNα后血小板减少和肝功能酶异常也更频繁地被观察到。未观察到危及生命的毒性。
