Fleming J S, Ackery D M, Walmsley B H, Karran S J
J Nucl Med. 1983 Dec;24(12):1108-13.
A technique is described for the measurement of the relative magnitudes of the hepatic-artery and portal-vein components of liver perfusion, using a gamma camera and on-line computer system. This ratio is obtained from analysis of the time variation in liver activity on the first pass following bolus intravenous injection of a Tc-99m-labeled radiocolloid. The arterial and portal components are separated by their times of arrival at the liver. These arrival times are evaluated from activity time variations for spleen, left ventricle, and left kidney. Physiological validation of the technique was provided in a digestion study in which normal volunteers showed a significant increase in the portal-vein component 1 hr after a meal relative to the fasting situation. These results are compared with those from studies by other workers. The uncertainties and limitations of the technique are discussed and potential clinical uses suggested.
本文描述了一种使用γ相机和在线计算机系统测量肝脏灌注中肝动脉和门静脉成分相对大小的技术。该比值通过对静脉推注Tc-99m标记的放射性胶体后首次通过时肝脏活性随时间变化的分析获得。动脉和门静脉成分根据它们到达肝脏的时间来分离。这些到达时间通过脾脏、左心室和左肾的活性时间变化来评估。在一项消化研究中对该技术进行了生理学验证，其中正常志愿者在进食后1小时门静脉成分相对于空腹状态有显著增加。将这些结果与其他研究人员的研究结果进行了比较。讨论了该技术的不确定性和局限性，并提出了潜在的临床应用。
