Aranda J V, Turmen T, Davis J, Trippenbach T, Grondin D, Zinman R, Watters G
J Pediatr. 1983 Dec;103(6):975-8. doi: 10.1016/s0022-3476(83)80735-5.
Abnormalities in control of breathing have been associated with near-miss sudden infant death syndrome. Because caffeine is a respiratory stimulant, its effect on breathing pattern was evaluated in 12 infants with infantile apnea. Caffeine induced a significant increase in ventilation, tidal volume, and mean inspiratory flow. In contrast, no changes were noted in inspiratory time, expiratory time, or total cycle duration. These effects were observed with plasma concentrations of caffeine ranging from 8 to 20 mg/L. Caffeine increases ventilation mainly by increasing central inspiratory drive, and not be effective timing (T1/TTOT). This drug may be of value in near-miss SIDS.
呼吸控制异常与濒死婴儿猝死综合征有关。由于咖啡因是一种呼吸兴奋剂，因此对12例婴儿呼吸暂停的婴儿评估了其对呼吸模式的影响。咖啡因使通气量、潮气量和平均吸气流量显著增加。相比之下，吸气时间、呼气时间或总周期时长没有变化。在血浆咖啡因浓度为8至20mg/L时观察到了这些效应。咖啡因主要通过增加中枢吸气驱动力而非有效时间（T1/TTOT）来增加通气。这种药物可能对濒死婴儿猝死综合征有价值。
