Kenigsberg K, Griswold P G, Buckley B J, Gootman N, Gootman P M
J Pediatr Surg. 1983 Oct;18(5):542-5. doi: 10.1016/s0022-3468(83)80355-8.
Twenty-six artificially ventilated newborn pigs were subjected to simulated gastroesophageal reflux; saline (10 cc) of varying pH was flushed through the esophagus from below. At a given pH threshold, reflex bradycardia, which could be blocked by atropine, was elicited. Transecting of the superior laryngeal nerves, the recurrent laryngeal nerves, and the pharyngeal plexus nerves did not block the reflex bradycardia. However, bypassing the regions superior to the esophagus with a shunt prevented the bradycardia. These results indicate that bradycardia caused by gastroesophageal reflux is independent of changes in ventilation and may be an important cause of sudden infant death.
26只人工通气的新生猪接受了模拟胃食管反流实验；用不同pH值的生理盐水（10毫升）从下方冲洗食管。在给定的pH阈值下，可引发反射性心动过缓，且该反射可被阿托品阻断。切断喉上神经、喉返神经和咽丛神经并不能阻断反射性心动过缓。然而，用分流管绕过食管上方区域可防止心动过缓。这些结果表明，胃食管反流引起的心动过缓与通气变化无关，可能是婴儿猝死的一个重要原因。
